Biomarker Test for Lou Gehrig’s Disease Useful in Diagnosing Canine Neurodegenerative Disease

Mizzou researchers seek clinical trial participants for further treatment study May 03, 2017 Story Contact(s): Jeff Sossamon COLUMBIA, Mo. – In 2009, Joan Coates, a veterinary neurologist, along with other researchers at the University of Missouri and the Broad Institute at MIT/Harvard, found a genetic link between degenerative myelopathy (DM) in dogs and amyotrophic lateral sclerosis

Treatment shows promise in models of fatal neurological disorders

April 25, 2017 At a Glance Researchers found that a gene-silencing drug can reverse or improve symptoms in mouse models of ataxia and amyotrophic lateral sclerosis. The results suggest a new possible therapy for these two untreatable neurological diseases. A drug designed to silence a gene called ataxin 2 improved neuron function in mouse models

A biomarker for tracking the progression of ALS

April 4, 2017  At a Glance Researchers discovered that levels of a protein in urine gradually increased in patients with ALS as their disease progressed over 2 years. These results suggest a potential biomarker to monitor disease progress and the effectiveness of therapies. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which motor

April 4th, 2017|Categories: ALS|Tags: , , , |

Surprising culprit in nerve cell damage identified

Findings suggest ways to block nerve cell damage in neurodegenerative diseases By Julia Evangelou Strait March 22, 2017 Nerve axons (left) serve as the electrical wiring of the nervous system. Scientists have implicated a specific molecule in triggering a self-destruct program in axons that leads to their degeneration (right). Since axonal degeneration is a common thread

Researcher Finds Evidence Probiotics May Alleviate Progression of ALS

Feb 2, 2017 - KCU staff An imbalance of bacteria in the digestive tract may contribute to the progression of Amyotrophic Lateral Sclerosis (ALS) according to new research led by KCU scientist Jingsong Zhou, PhD and Jun Sun, PhD of University of Illinois at Chicago (UIC). Their preliminary research suggests probiotics could be a potential

February 2nd, 2017|Categories: ALS, Around The State|Tags: , , , |

CIRM-Funded Clinical Trial for ALS Given Go Ahead to Treat Patients

October 24, 2016 Oakland, CA – An ingenious method that uses a patient as their own control has been given clearance to start a clinical trial to treat amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease. The California Institute for Regenerative Medicine (CIRM) is funding the trial. ALS is a devastating disease that

October 24th, 2016|Categories: ALS, Clinical Trials|Tags: , , |

From labs to lives: Self-replicating cells help treat neuro disorders

July 27, 2016 Scientists estimate that human bodies contain anywhere from 75 to 100 trillion cells. And of these cells, there are hundreds of different types. Yet, one cell type in particular has captured the fascination of assistant professor David Brafman: the human pluripotent stem cell (hPSC).Assistant professor David Brafman mentoring biomedical engineering junior Lexi

More Good News for Stem Cell Transplants in ALS

Pauline Anderson July 05, 2016 Medscape Transplantation of human spinal cord-derived neural stem cells (HSSCs) in patients with amyotrophic lateral sclerosis (ALS) is safe and does not accelerate progression of the disease, according to results of a new phase 2 study. A phase 1 single-center study of 15 patients, carried out at Emory University in Atlanta, Georgia, found

Jammed Up Cellular Highways May Initiate Dementia and ALS

Molecular therapy partially relieves havoc wreaked by gene mutation in human and fly cells August 26, 2015 FAST FACTS: The C9orf72 mutation is the most common known genetic risk factor for 40 percent of inherited cases of amyotrophic lateral sclerosis (ALS) and a similar percentage of inherited cases of frontotemporal dementia. Researchers say they have