Blindness

Stem Cell Therapy Shows Promise for Retinal Degeneration

Retinal pigment epithelial (RPE) cells derived from human embryonic stem cells can be safely transplanted into the eyes of patients with retinal degeneration, with early signs of vision gain, according to pioneers in the field. Two teams of researchers reported preliminary findings from phase 1 and phase 2 trials at the American Academy of Ophthalmology (AAO)

Glaucoma breakthrough by UNMC research team published in journal Stem Cells

A University of Nebraska Medical Center researcher has discovered that a common form of glaucoma that strikes adults may have early origin. The discovery, which is detailed in the August 9 issue of the journals Stem Cells, could result in earlier diagnosis and treatment of the disease that is the second leading cause of irreversible

September 26th, 2017|Categories: Blindness, Disease Specific|Tags: , |

Improving the longevity of functionally integrated stem cells in regenerative vision therapy

Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells January 12, 2017/Novato, California:  Stem cell therapies hold great promise for restoring function in a variety of degenerative conditions, but one of the logistical hurdles is how to ensure the cells survive in the

Novel gene-editing method improves vision in blind rats

December 6, 2016 At a Glance Scientists developed a targeted gene-replacement technique that can modify genes in both dividing and non-dividing cells in living animals. The method enabled replacement of a faulty gene in neurons and partially restored vision in blind rats. The technique thus holds promise as a potential tool for gene therapy. The

New gene-editing technology partially restores vision in blind animals

November 16, 2016Salk researchers have discovered, for the first time, how to place DNA in specific locations in non-dividing cells LA JOLLA—Salk Institute researchers have discovered a holy grail of gene editing—the ability to, for the first time, insert DNA at a target location into the non-dividing cells that make up the majority of adult

November 16th, 2016|Categories: Blindness|Tags: , , , , |

New, regenerative medicine approach developed to remove congenital cataracts in infants

Published on March 10, 2016 at 1:59 AM Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses. The treatment, which has been tested in animals

$11.9 million from NIH funds glaucoma study

Researchers to evaluate effectiveness of earlier efforts to prevent, delay blinding eye disease by Jim Dryden•February 26, 2016 ROBERT BOSTON PHOTO Michael A. Kass, MD, will lead a nationwide study to determine whether efforts to prevent or delay the onset of glaucoma have been effective over the course of two decades. Researchers at Washington University

CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells

A potential precision medicine approach for treating vision loss January 27, 2016 Columbia University Medical Center (CUMC) and University of Iowa scientists have used a new gene-editing technology called CRISPR to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at