Blood Disorders

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Genetic testing improves blood thinner dosing

Blood thinners, or anticoagulants, are often prescribed to help prevent blood clots that can lead to pulmonary embolism, heart attack, and stroke. Though effective at preventing these clots, warfarin can cause life-threatening bleeds. Warfarin has led to more emergency room visits for older people over the last decade than any other medication. This is because

$10 million DNA sequencing effort aims to shed light on lung diseases

Research is part of national project to understand genetic roots of heart, lung, blood, sleep disorders by Julia Evangelou Strait Washington University’s McDonnell Genome Institute has received $10 million from the National Heart, Lung and Blood Institute (NHLBI) to sequence the DNA of people from diverse ethnic backgrounds, in an effort to identify the genetic

Approaching a decades-old goal: Making blood stem cells from patients’ own cells

New technique raises possibility of making all types of blood cells to treat disease Date: May 17, 2017 Source: Boston Children's Hospital Summary: For the first time, researchers have generated blood-forming stem cells in the lab using pluripotent stem cells, which can make virtually every cell type in the body. The advance opens new avenues

Turning skin cells into blood vessel cells while keeping them young

April 6, 2017 - by Sharon Parmet Researchers from the University of Illinois at Chicago have identified a molecular switch that converts skin cells into cells that make up blood vessels, which could ultimately be used to repair damaged vessels in patients with heart disease or to engineer new vasculature in the lab. The technique, which

Missouri Researchers Join Hunt For One Of Medicine’s Elusive Quarries: Artificial Blood

By ALEX SMITH • APR 5, 2017 Former railroad worker Johnnie Matz has been donating blood, platelets and plasma at the Community Blood Center in Kansas City for 45 years. ALEX SMITH / KCUR 89.3 Medical researchers have made a lot of progress developing artificial versions of organs like the heart, lungs and kidneys, but

Major breakthrough in the manufacture of red blood cells

Press release issued: 24 March 2017 Researchers have generated the first immortalised cell lines which allow more efficient manufacture of red blood cells. The team, from the University of Bristol and NHS Blood and Transplant, were able to manufacture red blood cells in a more efficient scale than was previously possible. The results, published in

UCSF researchers find key to ‘tired’ blood and immune systems

Aging of Blood-Forming Stem Cells Is Linked to Defect in Cellular Recycling Process By Jeff Norris on March 02, 2017 A molecular key to aging of the blood and immune system has been discovered in new research conducted at UC San Francisco, raising hope that it may be possible to find a way to slow

New Drug Could Help Prevent Artery Disease in High-risk Patients

A recent study by researchers at the University of Missouri School of Medicine has shown that a protein inhibitor drug prevents these blockages, and could be a new therapeutic approach to prevent heart attack, stroke and other diseases caused by blocked blood vessels. Dec. 21, 2016- According to the American Heart Association, approximately 2,200 Americans

Scientists find culprit responsible for calcified blood vessels in kidney disease

Stem cell finding informs research to prevent hardening of arteries By Julia Evangelou Strait September 8, 2016 A new study indicates that stem cells called Gli1 cells (shown in red) are responsible for depositing calcium in the arteries, increasing the risk of atherosclerosis. Over time, the condition can lead to cardiovascular disease and is especially

Blood-forming stem cells likely hold the key to curing many types of disease

Science Friday July 20, 2016 · 7:45 AM EDT By Adam Wernick Researchers at Stanford are reviving a technique that can use uncontaminated, blood-forming stem cells to treat a patient with cancer, autoimmune deficiency and other diseases. Beginning in the 1960s, hematopoietic, or blood-forming, stem cells became the basis for bone marrow transplants used to treat cancer patients. Then, in the 1980s and