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New imaging technique shows effectiveness of Cystic Fibrosis drug

April 15, 2017 by Deidra Ashley Talissa Altes, MD, Chair of the Department of Radiology at the MU School of Medicine. Hyperpolarized helium MRI could aid in development of improved therapies for lung diseases According to the Cystic Fibrosis Foundation, more than 30,000 Americans are living with the disorder. It currently has no cure, though a

Researchers Develop Novel Wound-Healing Technology

Tue, 11/29/2016 - 2:10pm by Washington State University A WSU research team has successfully used a mild electric current to take on and beat drug-resistant bacterial infections, a technology that may eventually be used to treat chronic wound infections. The researchers report on their work in the online edition of npj Biofilms and Microbiomes. Led by Haluk

Scientists find way to create human stem cells with only 23 chromosomes, could revolutionize genetic research

BY DENIS SLATTERY, NEW YORK DAILY NEWS, Wednesday, March 16, 2016, 8:53 PM A scientific discovery unveiled Wednesday could revolutionize genetic research with new screening tools and therapies. Researchers from Columbia University Medical Center, the New York Stem Cell Foundation Research Institute and Hebrew University have found a way to create human stem cells with only 23

Engineering a permanent solution to genetic diseases

Aug. 10, 2015 - In his mind, Basil Hubbard can already picture a new world of therapeutic treatments for millions of patients just over the horizon. It’s a future in which diseases like muscular dystrophy, cystic fibrosis and many others are treated permanently through the science of genome engineering. Thanks to his latest work, Hubbard

Gene therapy for cystic fibrosis shows encouraging results

July 3, 2015 A therapy that replaces the faulty gene responsible for cystic fibrosis in patients' lungs has produced encouraging results in a major UK trial. The study was carried out by the UK Cystic Fibrosis Gene Therapy Consortium, a group of scientists and clinical teams from Imperial College London, the Universities of Oxford and

Targeting Cystic Fibrosis: Are Two Drugs Better than One?

Posted on May 26, 2015 by Dr. Francis Collins To explain the many challenges involved in turning scientific discoveries into treatments and cures, I often say, “Research is not a 100-yard dash, it’s a marathon.” Perhaps there is no better example of this than cystic fibrosis (CF). Back in 1989, I co-led the team that

Key Component in Protein that Causes Cystic Fibrosis Identified

In a study recently published in PNAS, a National Academy of Sciences journal, a team of cystic fibrosis researchers led by Tzyh-Chang Hwang, PhD, demonstrate how they identified a key mechanism that could influence the behavior of the CFTR protein and flow of chloride ions in and out of cells through the protein. Chloride is

Regenerative Medicine Study Underscores Lung Regeneration Capacity

April 28, 2015, Reid D'Amoco In diseases like cystic fibrosis, the lungs undergo constant healing and remodeling due to chronic infections. To better understand the repair mechanisms the lungs go through in diseases like CF and COPD, scientists have paid great attention to studying cellular regeneration. Scientists at the University of Pennsylvania and Duke University have discovered

Scientists grow ‘mini-lungs’ to aid the study of cystic fibrosis

Scientists at the University of Cambridge have successfully created ‘mini-lungs’ using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be used to test potential new drugs for this debilitating lung disease. We can use these 'mini-lungs' to learn more about key aspects of serious diseases –

Study sheds new light on asthma, COPD

March 17, 2015 By Julia Evangelou Strait Z. YURTSEVER When exposed to the protein CLCA1 (red), human cells start to express the chloride ion channel TMEM16A (green) on their surface. New research at Washington University suggests this protein and channel may work together in the over-production of mucus characteristic of diseases such as asthma and