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Serotonin Loss May Drive Cognitive Decline

Loss of the neurotransmitter serotonin may drive cognitive decline rather than simply being a by-product of memory problems, according to new findings that have potential implications for the prevention and treatment of mild cognitive impairment (MCI). Studies have consistently shown that serotonin degeneration occurs in normal aging and Alzheimer's disease (AD), but evidence for degeneration

SLU Surgeons Study ‘Awake Aneurysm Surgery’ for Better Outcomes

In a first time study published in the August edition of the Journal of Neurosurgery, Saint Louis University surgeons and researchers report that the use of conscious sedation – also called “awake brain surgery” – allowed them to make adjustments mid-surgery to lower risks during aneurysm surgery. The research was led by Saleem Abdulrauf, M.D.,

August 21st, 2017|Categories: Around The State|Tags: , , |

Gene Editing Spurs Hope for Transplanting Pig Organs Into Humans

In a striking advance that helps open the door to organ transplants from animals, researchers have created gene-edited piglets cleansed of viruses that might cause disease in humans. The experiments, reported on Thursday in the journal Science, may make it possible one day to transplant livers, hearts and other organs from pigs into humans, a

August 17th, 2017|Categories: General News|Tags: , , , |

NIH accelerates the use of genomics in clinical care

New funding awards focus on diverse and underserved populations. The National Institutes of Health (NIH) is awarding $18.9 million towards research that aims to accelerate the use of genome sequencing in clinical care. The new awards will generate innovative approaches and best practices to ensure that the effectiveness of genomic medicine can be applied to

August 14th, 2017|Categories: General News|Tags: , |

Increased Endometrial Cancer Rates Found in Women with High Levels of Cadmium

By Derek Thompson Researcher recommends women limit cadmium intake More than 31,000 new cases of endometrial cancer are expected to be diagnosed in 2017. Through a five-year observational study recently published in PLOS One, researchers at the University of Missouri found that women with increased levels of cadmium — a metal commonly found in foods

NCI study identifies essential genes for cancer immunotherapy

A new study identifies genes that are necessary in cancer cells for immunotherapy to work, addressing the problem of why some tumors don’t respond to immunotherapy or respond initially but then stop as tumor cells develop resistance to immunotherapy. The study, from the National Cancer Institute (NCI), was led by Nicholas Restifo, M.D., a senior

August 9th, 2017|Categories: Cancer, Disease Specific|Tags: , , |

Midlife cardiovascular risk factors may increase chances of dementia

A large, long-term study suggests that middle aged Americans who have vascular health risk factors, including diabetes, high blood pressure and smoking, have a greater chance of suffering from dementia later in life. The study, published in JAMA Neurology, was funded by the National Institutes of Health (NIH). “With an aging population, dementia is becoming

Protein-rich diet may help soothe inflamed gut

Immune cells patrol the gut to ensure that harmful microbes hidden in the food we eat don’t sneak into the body. Cells that are capable of triggering inflammation are balanced by cells that promote tolerance, protecting the body without damaging sensitive tissues. When the balance tilts too far toward inflammation, inflammatory bowel disease can result.

Postconception Genetic Mutations Contribute to Autism Risk

Mutations that occur after conception may play an important role in autism spectrum disorder (ASD), according to a study of nearly 6000 families that combined three genetic sequencing techniques. "Our study has uncovered new mutations in ASD, as well as provided additional evidence for some genes that have been previously reported in ASD," first author,

August 4th, 2017|Categories: Uncategorized|

Early-Life Depression Boosts Alzheimer’s Risk

Depression that starts early in life increases the risk for Alzheimer's disease (AD), as demonstrated in findings from a large, longitudinal study that is the first to report this association. This relationship has not been seen in earlier studies, Lena Johansson, PhD, Institute of Neuroscience and Physiology, Sahlgrenska Academy Center for Aging and Health, the