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Stem cells edited to fight arthritis

Goal is vaccine that targets inflammation in joints by Jim Dryden•April 27, 2017 ELLA MARUSHCHENKO Using CRISPR technology, a team of researchers led by Farshid Guilak, PhD, at Washington University School of Medicine in St. Louis, rewired stem cells' genetic circuits to produce an anti-inflammatory arthritis drug when the cells encounter inflammation. The technique eventually

Nanoparticles can travel from lungs to blood, possibly explaining risks to heart

April 26, 2017 (Nanowerk News) Tiny particles in air pollution have been associated with cardiovascular disease, which can lead to premature death. But how particles inhaled into the lungs can affect blood vessels and the heart has remained a mystery. Now, scientists have found evidence in human and animal studies that inhaled nanoparticles can travel

Bare bones: Making bones transparent

April 26, 2017 (Nanowerk News) Ten years ago, the bones currently in your body did not actually exist. Like skin, bone is constantly renewing itself, shedding old tissue and growing it anew from stem cells in the bone marrow. Now, a new technique developed at Caltech can render intact bones transparent, allowing researchers to observe

Treatment shows promise in models of fatal neurological disorders

April 25, 2017 At a Glance Researchers found that a gene-silencing drug can reverse or improve symptoms in mouse models of ataxia and amyotrophic lateral sclerosis. The results suggest a new possible therapy for these two untreatable neurological diseases. A drug designed to silence a gene called ataxin 2 improved neuron function in mouse models

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types

UTSW researchers who developed a nanoparticle vaccine for cancer immunotherapy include (l-r) Drs. Min Luo, Jinming Gao, Zhijian “James” Chen, Zhaohui Wang, and Hua Wang. DALLAS – April 24, 2017 – Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types. The nanovaccine consists of tumor antigens

Antibody helps detect protein implicated in Alzheimer’s, other diseases

May lead to novel ways to diagnose, monitor brain injury by Tamara Bhandari•April 19, 2017 HUY MACH Researchers use mouse brains (above) to study ways to measure the brain protein tau, which plays a role in neurodegenerative diseases such as Alzheimer's. A team led by scientists at Washington University School of Medicine in St. Louis

New Bone-In Technique Tests Therapies for Breast Cancer Metastasis

Fri, 04/21/2017 - 10:14am by Baylor College of Medicine Dr. Xiang Zhang, associate professor of molecular and cellular biology and the Lester and Sue Smith Breast Center, and McNair Scholar at Baylor College of Medicine. Credit: Baylor College of Medicine A new laboratory technique developed by researchers at Baylor College of Medicine and other institutions can

Scientists discover two repurposed drugs that arrest neurodegeneration in mice

University of Cambridge April 20, 2017 A team of scientists who a few years ago identified a major pathway that leads to brain cell death in mice, have now found two drugs that block the pathway and prevent neurodegeneration. The drugs caused minimal side effects in the mice and one is already licensed for use

Antibody helps detect protein implicated in Alzheimer’s, other diseases

May lead to novel ways to diagnose, monitor brain injury by Tamara Bhandari•April 19, 2017 HUY MACH Researchers use mouse brains (above) to study ways to measure the brain protein tau, which plays a role in neurodegenerative diseases such as Alzheimer's. A team led by scientists at Washington University School of Medicine in St. Louis

Could a Dog Vaccine Help Save Kids With Brain Cancer?

By: Laura Goldman, Care2.com, April 17, 2017 The statistics are grim: About 60 to 70 percent of children who have glioblastoma, a form of brain cancer, do not survive more than two years. This fast-growing cancer is resistant to traditional treatments like radiation and chemotherapy. For dogs, cancer statistics are also grim. More than 6