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Kidney disease increases risk of diabetes, study shows

Diabetes is known to increase a person’s risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes. Further, the researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes

In Lab Research, Scientists Slow Progression of a Fatal Form of Muscular Dystrophy

In a paper published in the Nature journal Scientific Reports, Saint Louis University researchers report that a new drug reduces fibrosis (scarring) and prevents loss of muscle function in an animal model of Duchenne muscular dystrophy (DMD), providing a promising approach in designing new medications for those suffering from DMD. DMD is a fatal form of

Alzheimer’s damage in mice reduced with compound that targets APOE gene

People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer’s disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer’s protein amyloid beta. “Scientists have been interested in APOE

Good News from Trio of Phase One Zika Vaccine Trials

In early results published in the Lancet, researchers report that an investigational Zika vaccine was well-tolerated and stimulated potentially protective immune responses in three phase 1 clinical trials, one of which was conducted at Saint Louis University. More than 90 percent of study volunteers in the three trials who received the investigational vaccine demonstrated an immune

December 7th, 2017|Categories: Around The State, Clinical Trials|Tags: , , |

SLU Researchers Discover BRCA Cancer Cells’ Last Defense

In a new paper published in Nature Communications, a team led by Saint Louis University researcher Alessandro Vindigni, Ph.D. shares new information about how BRCA-deficient cancer cells operate, interact with chemotherapy drugs and what may be their last-ditch effort to survive. Researchers hope their findings may lead to improved chemotherapy drugs and shed light on why

November 29th, 2017|Categories: Around The State, Cancer, Disease Specific|Tags: , , , |

Cutting NIH budget could cripple drug development

A proposal to slash funding for the National Institutes of Health (NIH) could severely impair the development of new, life-saving drugs, according to a new analysis by researchers at Washington University School of Medicine in St. Louis. NIH funding supports the early research needed to develop new, innovative drugs. President Donald Trump’s proposed budget calls

November 27th, 2017|Categories: Around The State, General News|Tags: , , |

In autism, too many brain connections may be at root of condition

A defective gene linked to autism influences how neurons connect and communicate with each other in the brain, according to a study from Washington University School of Medicine in St. Louis. Rodents that lack the gene form too many connections between brain neurons and have difficulty learning. The findings, published Nov. 2 in Nature Communications,

November 9th, 2017|Categories: Around The State, Autism, Disease Specific|Tags: , , , |

SLU Researcher Draws Bulls Eye Around Muscular Dystrophy Drug Targets

In a recent paper published in the journal Skeletal Muscle, a Saint Louis University researcher reports success in identifying new drug targets that potentially could slow or halt the progression of a form muscular dystrophy, an illness characterized by progressive muscle degeneration. Francis M. Sverdrup, Ph.D., research fellow in the Saint Louis University Department of Biochemistry and