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$3.7 million to help research neurological disorders linked to manganese

Manganese – found in smoke from steel production and coal fires – has been linked to a range of neurological problems often seen with Parkinson’s disease: slowness, stiffness, tremors, anxiety, depression, cognitive changes, and difficulty walking and speaking. Decades ago, federal environmental and public health agencies established manganese-concentration levels of concern for human health, but

Biologists Identify Possible New Strategy for Halting Brain Tumors

MIT biologists have discovered a fundamental mechanism that helps brain tumors called glioblastomas grow aggressively. After blocking this mechanism in mice, the researchers were able to halt tumor growth. The researchers also identified a genetic marker that could be used to predict which patients would most likely benefit from this type of treatment. Glioblastoma is

October 9th, 2017|Categories: Cancer, Disease Specific|Tags: , , |

Gene Immunotherapy Protects Against MS in Mice

A potent and long-lasting gene immunotherapy approach prevents and reverses symptoms of multiple sclerosis in mice, according to a study published September 21st in the journal Molecular Therapy. Multiple sclerosis is an autoimmune disease in which T cells destroy the myelin sheath--the material that surrounds and protects nerve cells in the brain and spinal cord. The

Tension Makes the Heart Grow Stronger

By taking videos of a tiny beating zebrafish heart as it reconstructs its covering in a petri dish, scientists have captured unexpected dynamics of cells involved in tissue regeneration. They found that the depleted heart tissue regenerates itself in a wave, led by a front of fast-moving, supersized cells and trailed by smaller cells that

Chemo-loaded nanoparticles target breast cancer that has spread to bone

Breast cancer that spreads often infiltrates bone, causing fractures and intense pain. In such cases, chemotherapy is ineffective because the environment of the bone protects the tumor, even as the drug has toxic side effects elsewhere in the body. Now, scientists at Washington University School of Medicine in St. Louis have developed a nanoparticle that

Bone Marrow Concentrate Improves Joint Transplants

Biologic joint restoration using donor tissue instead of traditional metal and plastic may be an option for active patients with joint defects. Although recovery from a biologic joint repair is typically longer than traditional replacement, successful biologic restoration allows patients to return to full activity. However, in some cases, the transplanted bone does not heal

Genetic testing improves blood thinner dosing

Blood thinners, or anticoagulants, are often prescribed to help prevent blood clots that can lead to pulmonary embolism, heart attack, and stroke. Though effective at preventing these clots, warfarin can cause life-threatening bleeds. Warfarin has led to more emergency room visits for older people over the last decade than any other medication. This is because

Multilevel Approach Improves Pediatric Asthma Care

Using a hospital-driven, integrated, multilevel, quality improvement approach that extends into the community leads to improved asthma outcomes among pediatric patients with asthma, a new study shows. Carolyn M. Kercsmar, MD, from the Cincinnati Children's Hospital Medical Center, Ohio, and colleagues published the results of their study online September 18 in JAMA Pediatrics. "During the

October 2nd, 2017|Categories: Disease Specific|Tags: , |

Novel Protein Signals Rapid Hippocampal Atrophy in AD

The presence of TAR DNA-binding protein 43 (TDP-43) in the hippocampus on postmortem examination is associated with increased rates of hippocampal atrophy in patients with Alzheimer's disease (AD), new research suggests. This association was greatest in individuals who had an intermediate or high likelihood of having AD (ie, neurofibrillary tangle stages B2 and B3), but