New Alzheimer’s Prevention Trial in Young People Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer’s disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer’s prevention trials, this one will enroll people before
NIH Researchers Identify Potential AMD Drugs with Stem-cell Based Research Tool Using a stem-cell-derived model, researchers have identified two drug candidates that may slow dry age-related macular degeneration (AMD), a leading cause of blindness for which no treatment exists. The scientists, from the National Eye Institute (NEI), part of the
Improving Drug Options for Colorectal Cancer Patients Patients with colorectal cancer were among the first to receive targeted therapies. These drugs aim to block the cancer-causing proteins that trigger out-of-control cell growth while sparing healthy tissues. But some patients are not eligible for these treatments because they have cancer-promoting mutations
Antipsychotic Drugs May Increase Risk of Breast Cancer Tracking medications provided to over a half million U.S. women, researchers at Washington University School of Medicine in St. Louis have found that many commonly prescribed older antipsychotic medications, and some newer ones, are associated with a significant increase in risk of
Op-Ed: Huntington’s Key Protein mhTT — Best Way for CRISPR to Prove What It Can Do? Huntington’s Disease is a hideous progressive disease. One of the primary causes is a mutant protein called mhTT, which is a corrupted essential protein in spinal fluid. mhTT replaces the proper protein, a protein
Type 1 Diabetes: Study Uncovers New Avenue Toward Treatment Scientists have already implicated a particular part of a chromosome in type 1 diabetes. However, they did not understand exactly why this region — known as locus 3p21.31 — influences risk. The current study adds more detail. Read more...
In an Astonishing Feat, a New Drug Reversed Paralysis in Mice With Spinal Cord Injury US scientists have developed a new form of drug that promotes the regeneration of cells and reversed paralysis in mice with spinal injuries, allowing them to walk again within four weeks of treatment. Read more...
Cancer Moonshot Grant Funds Research Into Reducing Health Disparities Washington University School of Medicine in St. Louis has received a $17 million grant from the National Institutes of Health (NIH) to address disparities in cancer research, treatment and outcomes in underrepresented populations. The research, funded through the National Cancer Institute’s
Turning CAR-T Tech Against Solid Tumors by Targeting Protein Fragments in Cancer Cells CAR-T therapies, which arm a patient’s own immune cells with cancer-fighting proteins, are currently used to treat some patients with blood cancers. But the technology has been hard to apply to other cancers, partly because of a
Scientists Reveal How Alzheimer’s Progresses in the Brain In people with Alzheimer’s, plaques of a misfolded protein called beta-amyloid, and fibrous tangles of another misfolded protein called tau, accumulate in the brain and kill nerve cells. This gradual loss of nerve cells causes shrinkage of the brain and eventually interferes