Alzheimer’s Treatment Proves Effective at Preventing Inflammation, Failure of Orthopedic Implants From a simple tooth to a major knee replacement, dental and orthopedic implant surgeries to common around the globe. However, these procedures can fail due to the immune system’s response to bacteria or metal particles coming off the implants.
Draining Brain’s Debris Enhances Alzheimer’s Therapies in Mice Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving
Understanding How Cancer Can Relapse In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations — oncogenic RAS or RASV12 —
Scientists Find Genetic Link to Clogged Arteries High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays
Zika Virus Helps Destroy Deadly Brain Cancer in Mice The Zika virus that ravaged the Americas, leaving many babies with permanent brain damage, may have a silver lining. The virus can activate immune cells to destroy an aggressive brain cancer in mice, giving a powerful boost to an immunotherapy drug
International Alzheimer’s Clinical Trial to Test Tau Drugs A worldwide clinical trial aimed at finding treatments for Alzheimer’s disease has expanded to include investigational drugs targeting a harmful form of the brain protein tau. The trial, known as the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and led by Washington
Developing a Targeted Delivery System to Treat Cancer In the ongoing battle to find ways to treat cancer, a team at the University of Missouri is addressing the problem from multiple angles, but with a precision approach. Cancer patients are often given chemotherapy, cancer-fighting drugs that kill cancerous cells and
Bristol Myers Squibb Wins First CAR-T Therapy Approval in Multiple Myeloma The FDA has approved a Bristol Myers Squibb cell therapy made by engineering a patient’s immune cells to target a cancer protein called BCMA. The regulatory decision for Abecma in multiple myeloma gives BMS its second approved CAR-T therapy.
Three UC’s Join Forces to Launch CRISPR Clinical Trial Targeting Sickle Cell Disease The University of California, San Francisco (UCSF), in collaboration with UC Berkeley (UCB) and UC Los Angeles (UCLA), have been given permission by the US Food and Drug Administration (FDA) to launch a first-in-human clinical trial using
Promising Role for Whole Genome Sequencing in Guiding Blood Cancer Treatment For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes. Some of these tests rely on