From labs to lives: Self-replicating cells help treat neuro disorders

July 27, 2016 Scientists estimate that human bodies contain anywhere from 75 to 100 trillion cells. And of these cells, there are hundreds of different types. Yet, one cell type in particular has captured the fascination of assistant professor David Brafman: the human pluripotent stem cell (hPSC).Assistant professor David Brafman mentoring biomedical engineering junior Lexi

More Good News for Stem Cell Transplants in ALS

Pauline Anderson July 05, 2016 Medscape Transplantation of human spinal cord-derived neural stem cells (HSSCs) in patients with amyotrophic lateral sclerosis (ALS) is safe and does not accelerate progression of the disease, according to results of a new phase 2 study. A phase 1 single-center study of 15 patients, carried out at Emory University in Atlanta, Georgia, found

Jammed Up Cellular Highways May Initiate Dementia and ALS

Molecular therapy partially relieves havoc wreaked by gene mutation in human and fly cells August 26, 2015 FAST FACTS: The C9orf72 mutation is the most common known genetic risk factor for 40 percent of inherited cases of amyotrophic lateral sclerosis (ALS) and a similar percentage of inherited cases of frontotemporal dementia. Researchers say they have

Biogen, ALS Association, and Columbia University Med Center to Explore ALS Genetics

Source: © iceteastock/Fotolia.com Aug. 18, 2015 - Biogen, the ALS Association, and Columbia UniversityMedical Center (CUMC) agreed to collaborate to better understand the differences and commonalities in the ALS disease process and how genes influence the clinical features of the disease. The project, “Genomic Translation for ALS Clinical care” (GTAC), will involve a combination of next-generation

Neurons’ broken machinery piles up in ALS

Wednesday, August 12, 2015, 11 a.m. EDT NIH scientists identify a transport defect in a model of familial ALS A healthy motor neuron needs to transport its damaged components from the nerve-muscle connection all the way back to the cell body in the spinal cord. If it cannot, the defective components pile up and the

August 12th, 2015|Categories: ALS|Tags: , , , |

Research Sheds Light on How Neurons Control Muscle Movement

New research involving people diagnosed with Lou Gehrig’s disease sheds light on how individual neurons control muscle movement in humans — and could help in the development of better brain-controlled prosthetic devices. JUN 232015 Studying the brain activity of two patients with Lou Gehrig's disease has given researchers insight into how neurons control muscle movement.

A New Grasp on Robotic Glove

Mon, 06/08/2015 - 10:15am- Harvard University The soft robotic glove could help patients suffering from muscular dystrophy, amyotrophic lateral sclerosis, incomplete spinal cord injury, or other hand impairments regain some independence and control of their environment. (Photo: Courtesy of Wyss Institute at Harvard University)Having achieved promising results in proof-of-concept prototyping and experimental testing, a soft robotic

Major pathway identified in nerve cell death offers hope for therapies

April 23, 2015 By Caroline Arbanas ROBERT BOSTON PHOTO MD/PhD student Josiah Gerdts (left) and Jeffrey Milbrandt, MD, PhD, head of the Department of Genetics at Washington University School of Medicine, have identified a major pathway in the death of nerve axons, which carry messages between nerve cells. The finding provides a foundation for developing

CIRM-Funded Scientists Build a Better Neuron; Gain New Insight into Motor Neuron Disease

APRIL 15, 2015 / ANNE HOLDEN, blog.cirm.ca.gov Each individual muscle in our body—no matter how large or how small—is controlled by several types of motor neurons. Damage to one or more types of these neurons can give rise to some of the most devastating motor neuron diseases, many of which have no cure. But now, stem