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Novel Protein Signals Rapid Hippocampal Atrophy in AD

The presence of TAR DNA-binding protein 43 (TDP-43) in the hippocampus on postmortem examination is associated with increased rates of hippocampal atrophy in patients with Alzheimer's disease (AD), new research suggests. This association was greatest in individuals who had an intermediate or high likelihood of having AD (ie, neurofibrillary tangle stages B2 and B3), but

Lithium in Drinking Water May Lower Dementia Risk

Higher long-term lithium exposure from drinking water may be associated with a lower incidence of dementia, a large population-based study suggests. "This is the first study ever investigating the association between lithium in drinking water and onset of dementia," Lars Vedel Kessing, MD, DMSc, from the University of Copenhagen, Denmark, told Medscape Medical News. "If

Serotonin Loss May Drive Cognitive Decline

Loss of the neurotransmitter serotonin may drive cognitive decline rather than simply being a by-product of memory problems, according to new findings that have potential implications for the prevention and treatment of mild cognitive impairment (MCI). Studies have consistently shown that serotonin degeneration occurs in normal aging and Alzheimer's disease (AD), but evidence for degeneration

Midlife cardiovascular risk factors may increase chances of dementia

A large, long-term study suggests that middle aged Americans who have vascular health risk factors, including diabetes, high blood pressure and smoking, have a greater chance of suffering from dementia later in life. The study, published in JAMA Neurology, was funded by the National Institutes of Health (NIH). “With an aging population, dementia is becoming

Early-Life Depression Boosts Alzheimer’s Risk

Depression that starts early in life increases the risk for Alzheimer's disease (AD), as demonstrated in findings from a large, longitudinal study that is the first to report this association. This relationship has not been seen in earlier studies, Lena Johansson, PhD, Institute of Neuroscience and Physiology, Sahlgrenska Academy Center for Aging and Health, the

New Test Paves Way for Potential Treatments to Target Alzheimer’s

by University of Bradford A simple methodology for capturing proteins implicated in the development of Alzheimer's disease and other conditions has been developed by researchers at the University of Bradford and University of Dundee. The new methodology involves easily trapping proteins that bear a specific modification that can provide potential markers for conditions. The specific

Blood test IDs key Alzheimer’s marker

Decades before people with Alzheimer’s disease develop memory loss and confusion, their brains become dotted with plaques made of a sticky protein – called amyloid beta – that is thought to contribute to the disease and its progression. Currently, the only way to detect amyloid beta in the brain is via PET scanning, which is

SLU Researchers Study Relationship Between Diabetes Drug, Dementia

ST. LOUIS – Saint Louis University researchers have received a $443,636 grant from the National Institute on Aging to investigate the relationship between the diabetes drug Metformin and dementia risk. Jeffrey Scherrer, Ph.D., professor and research director in the department of family and community medicine at Saint Louis University, said this is the first study of

More Evidence Links Sleep to Alzheimer’s Disease

Researchers have uncovered new evidence of a link between disturbed sleep and Alzheimer's disease (AD) that involves neuronal damage and inflammation in addition to amyloid plaques. Investigators at the University of Wisconsin-Madison found that self-report of inadequate sleep and greater daytime sleepiness in older, middle-aged, cognitively normal persons is associated with cerebrospinal fluid (CSF) biomarkers

July 8th, 2017|Categories: Alzheimer's/Dementia|Tags: , , |