Alzheimer’s/Dementia

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New Clues to Alzheimer’s Disease

Researchers probing the complexities of Alzheimer’s disease have detected issues involving cellular energy production, and those problems may be an important contributor to the late-onset form of the illness. A team at Harvard-affiliated McLean Hospital tested the cells of late-onset Alzheimer’s patients and found malfunctions in their energy production, including problems with the health of

December 13th, 2017|Categories: Alzheimer's/Dementia, Disease Specific|Tags: , , |

New forecast shows 6 million with Alzheimer’s disease, cognitive impairment

Using new methodology, scientists calculate that approximately 6 million American adults have Alzheimer’s disease or mild cognitive impairment, which can sometimes be a precursor to the disease. The estimate, funded by the National Institutes of Health, also forecasts that these numbers will more than double to 15 million by 2060, as the population ages. The

Alzheimer’s damage in mice reduced with compound that targets APOE gene

People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer’s disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer’s protein amyloid beta. “Scientists have been interested in APOE

Brain activity ripples linked to creation of long-term memories

While we’re asleep, the brain is working to store new information as long-term memories. Storing a memory likely involves interactions between the brain’s hippocampus and parts of the cortex. Scientists have been trying to determine the precise connections by examining electrical activity within these regions of the brain. When hundreds or thousands of nerve cells,

November 25th, 2017|Categories: Alzheimer's/Dementia, Disease Specific|Tags: , , |

Higher brain glucose levels may mean more severe Alzheimer’s

For the first time, scientists have found a connection between abnormalities in how the brain breaks down glucose and the severity of the signature amyloid plaques and tangles in the brain, as well as the onset of eventual outward symptoms, of Alzheimer’s disease. The study was supported by the National Institute on Aging (NIA), part

Research: Vaccinating Against Psoriasis, Allergies and Alzheimer’s a Possibility

Research from the Universities of Dundee and Oxford has shown how combining the tetanus vaccine with a viral particle that normally affects cucumbers can be used to treat psoriasis and allergies, and may even protect against Alzheimer's disease. Scientists led by Dundee's Dr John Foerster and Oxford's Professor Martin Bachmann, were able to take the

Novel Protein Signals Rapid Hippocampal Atrophy in AD

The presence of TAR DNA-binding protein 43 (TDP-43) in the hippocampus on postmortem examination is associated with increased rates of hippocampal atrophy in patients with Alzheimer's disease (AD), new research suggests. This association was greatest in individuals who had an intermediate or high likelihood of having AD (ie, neurofibrillary tangle stages B2 and B3), but

Lithium in Drinking Water May Lower Dementia Risk

Higher long-term lithium exposure from drinking water may be associated with a lower incidence of dementia, a large population-based study suggests. "This is the first study ever investigating the association between lithium in drinking water and onset of dementia," Lars Vedel Kessing, MD, DMSc, from the University of Copenhagen, Denmark, told Medscape Medical News. "If

Serotonin Loss May Drive Cognitive Decline

Loss of the neurotransmitter serotonin may drive cognitive decline rather than simply being a by-product of memory problems, according to new findings that have potential implications for the prevention and treatment of mild cognitive impairment (MCI). Studies have consistently shown that serotonin degeneration occurs in normal aging and Alzheimer's disease (AD), but evidence for degeneration