Autoimmune Diseases

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Drug compound shows promise against rheumatoid arthritis

Scientists have designed a new drug compound that dials down inflammation, suggesting possible future uses against autoimmune disorders such as rheumatoid arthritis. The new inhibitor is more selective than other compounds designed to target the same inflammatory pathway, according to new research from Washington University School of Medicine in St. Louis. Such precision, along with

Scientists Discover New Causes of Cellular Decline in Prematurely Aging Kids

In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease. The data points to cellular replication stress and a mistaken innate immune response as culprits, and the team found success in the laboratory in blocking these processes

Immune Cells Mistake Heart Attacks for Viral Infections

A study led by Kevin King, a bioengineer and physician at the University of California San Diego, has found that the immune system plays a surprising role in the aftermath of heart attacks. The research could lead to new therapeutic strategies for heart disease The team, which also includes researchers from the Center for Systems

New clues found to common respiratory virus

Discovery provides potential target for vaccines, treatments by Tamara Bhandari By age 2, most children have been infected with respiratory syncytial virus (RSV), which usually causes only mild cold symptoms. But people with weakened immune systems, such as infants and the elderly, can face serious complications, including pneumonia and – in some cases – death.

Scientists map surface of immune cells

June 12, 2015 (Helmholtz Zentrum München) The team headed by Dr. Kathrin Suttner, who, together with Prof. Dr. Carsten Schmidt-Weber, heads the airway immunology research group at the Helmholtz Zentrum München and Technische Universität München, concentrated its work on the so-called naive CD4+ T cells. They are a precursor form of T cells and form

Discovery could help reverse glucocorticoid resistance in some young leukemia patients

St. Jude Children’s Research Hospital study lays the foundation for more effective treatment of childhood leukemia and a wide range of other disorders using small molecules to reverse glucocorticoid resistance Memphis, Tennessee, May 4, 2015 Researchers led by St. Jude Children’s Research Hospital scientists have identified a mechanism that helps leukemia cells resist glucocorticoids, a

Newly Enlisted T-Cell ‘Policemen’ Can Slow Down Run-Away Immune System, SLU Scientist Says

March 30, 2015 Carrie Bebermeyer, Medical Center Communications, Saint Louis University ST. LOUIS — In research published in the March issue of Immunity, Saint Louis University scientists led by Daniel Hawiger, M.D., Ph.D., assistant professor of molecular microbiology and immunology, have discovered that potentially aggressive T-cells that might lead to auto-immune disease can instead be enlisted to

‘Most Comprehensive Map’ of Human Epigenomes Is Unveiled

UCSF Researcher Leads One of Four Major U.S. Centers in Global Effort By Laura Kurtzman on February 18, 2015 Two dozen scientific papers published online simultaneously on Feb. 18, 2015 present the first comprehensive maps and analyses of the epigenomes of a wide array of human cell and tissue types. Epigenomes are patterns of chemical

Breakthrough Research at UH May Lead to Novel Natural-Derived Lupus Treatment

Bio News Texas, by Leonore Mateus Ferrara ~ September 23, 2014 A new treatment for lupus may have been discovered by a group of biomedical engineers from the University of Houston (UH) in Texas, who have developed a drug that, unlike the current treatments for the disease, does not have a long list of side

$4.9 million grant to fund AIDS research

Washington University in St. Louis, by Michael C. Purdy ~ January 16, 2014 The AIDS Clinical Trials Site at Washington University School of Medicine in St. Louis has been awarded a National Institutes of Health (NIH) grant that supports testing of treatments for HIV, AIDS and the many complications they cause. The grant, from the