Blindness

Improving the longevity of functionally integrated stem cells in regenerative vision therapy

Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells January 12, 2017/Novato, California:  Stem cell therapies hold great promise for restoring function in a variety of degenerative conditions, but one of the logistical hurdles is how to ensure the cells survive in the

Novel gene-editing method improves vision in blind rats

December 6, 2016 At a Glance Scientists developed a targeted gene-replacement technique that can modify genes in both dividing and non-dividing cells in living animals. The method enabled replacement of a faulty gene in neurons and partially restored vision in blind rats. The technique thus holds promise as a potential tool for gene therapy. The

New gene-editing technology partially restores vision in blind animals

November 16, 2016Salk researchers have discovered, for the first time, how to place DNA in specific locations in non-dividing cells LA JOLLA—Salk Institute researchers have discovered a holy grail of gene editing—the ability to, for the first time, insert DNA at a target location into the non-dividing cells that make up the majority of adult

November 16th, 2016|Categories: Blindness|Tags: , , , , |

New, regenerative medicine approach developed to remove congenital cataracts in infants

Published on March 10, 2016 at 1:59 AM Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses. The treatment, which has been tested in animals

$11.9 million from NIH funds glaucoma study

Researchers to evaluate effectiveness of earlier efforts to prevent, delay blinding eye disease by Jim Dryden•February 26, 2016 ROBERT BOSTON PHOTO Michael A. Kass, MD, will lead a nationwide study to determine whether efforts to prevent or delay the onset of glaucoma have been effective over the course of two decades. Researchers at Washington University

CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells

A potential precision medicine approach for treating vision loss January 27, 2016 Columbia University Medical Center (CUMC) and University of Iowa scientists have used a new gene-editing technology called CRISPR to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at

National honor for helping “the blind see”

JANUARY 7, 2016 / KEVIN MCCORMACK, CIRM blog Those of us fortunate to have good health take so many things for granted, not the least of which is our ability to see. But, according to the World Health Organization, there are 39 million people worldwide who are blind, and another 246 million who are visually

Some Stem Cells Are Rejected, Some Aren’t, Says iPSC Work

Wed, 10/21/2015 - 9:38am Cynthia Fox, Science Writer Embryonic stem (ES) cell-like stem cells made from adult cells—and morphed into eye cells—are not rejected by the immune system, according to “humanized mouse” data in Cell Stem Cell. Coming alongside news that the first UK macular degeneration patient received eye cells made from normal ES cells,

A new treatment for macular degeneration

A patient receives the first human eye cell transplant developed by a UCSB neuroscientist who founded the London Project to Cure Blindness By Julie Cohen Monday, September 28, 2015 - Santa Barbara, CA A clinical trial using stem cell-derived ocular cells for the treatment of wet age-related macular degeneration (AMD) has been initiated in England. This was