Understanding How Cancer Can Relapse In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations — oncogenic RAS or RASV12 —
Zika Virus Helps Destroy Deadly Brain Cancer in Mice The Zika virus that ravaged the Americas, leaving many babies with permanent brain damage, may have a silver lining. The virus can activate immune cells to destroy an aggressive brain cancer in mice, giving a powerful boost to an immunotherapy drug
Developing a Targeted Delivery System to Treat Cancer In the ongoing battle to find ways to treat cancer, a team at the University of Missouri is addressing the problem from multiple angles, but with a precision approach. Cancer patients are often given chemotherapy, cancer-fighting drugs that kill cancerous cells and
Bristol Myers Squibb Wins First CAR-T Therapy Approval in Multiple Myeloma The FDA has approved a Bristol Myers Squibb cell therapy made by engineering a patient’s immune cells to target a cancer protein called BCMA. The regulatory decision for Abecma in multiple myeloma gives BMS its second approved CAR-T therapy.
Promising Role for Whole Genome Sequencing in Guiding Blood Cancer Treatment For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes. Some of these tests rely on
Salk Team Reveals Never-Before-Seen Antibody Binding, Informing Both Liver Cancer and Antibody Design
Salk Team Reveals Never-Before-Seen Antibody Binding, Informing Both Liver Cancer and Antibody Design In structural biology, some molecules are so unusual they can only be captured with a unique set of tools. That’s precisely how a multi-institutional research team led by Salk scientists defined how antibodies can recognize a compound
Killing Cancer by Unleashing the Body’s Own Immune System The body’s immune system is the first line of defense against infections like bacteria, viruses or cancers. Some cancers, however, have developed the art of molecular deception to avoid destruction by the body’s immune system. However, a University of Missouri researcher
Nanotechnologies to Help in New Cancer Treatment Strategy A new project – ULISES – is set to develop an immunologic-based treatment strategy where cancer cells are reprogrammed to become “visible” to the patients’ immune system. Read more...
Engineering Stem Cells to Treat Bone Cancer Over the past decades, stem cells are being broadly used as regenerative medicine for repairing or replacing tissues that are damaged due to injury or diseases. With the advancement in stem cell therapy, scientists have now engineered stem cells that can effectively treat
A Potential Cause of CAR T Side Effects, and A Path Forward Chimeric antigen receptor (CAR) T cell therapy has revolutionized treatment of leukemia, lymphoma, and multiple myeloma. But some people who have received this treatment experience neurotoxicity, or damage to the brain or nervous system. Read more...