Heart Disease

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Researchers use stem cells to regenerate the external layer of a human heart

By Stefanie Tomlinson January 11, 2017 UNIVERSITY PARK, Pa. — A process using human stem cells can generate the cells that cover the external surface of a human heart — epicardium cells — according to a multidisciplinary team of researchers. "In 2012, we discovered that if we treated human stem cells with chemicals that sequentially

New Drug Could Help Prevent Artery Disease in High-risk Patients

A recent study by researchers at the University of Missouri School of Medicine has shown that a protein inhibitor drug prevents these blockages, and could be a new therapeutic approach to prevent heart attack, stroke and other diseases caused by blocked blood vessels. Dec. 21, 2016- According to the American Heart Association, approximately 2,200 Americans

Scientists Create Heart Cells Better, Faster, Stronger

By Dana G. Smith, PhD / Gladstone News / November 10, 2016 Tamer Mohamed, PhD, (left) and Deepak Srivastava, MD, identified two chemicals that improve the speed, quantity, and quality of direct cardiac reprogramming, bringing the technology one step closer to regenerating damaged hearts in patients. [Photo: Chris Goodfellow, Gladstone Institutes] Scientists at the Gladstone

Scientists find culprit responsible for calcified blood vessels in kidney disease

Stem cell finding informs research to prevent hardening of arteries By Julia Evangelou Strait September 8, 2016 A new study indicates that stem cells called Gli1 cells (shown in red) are responsible for depositing calcium in the arteries, increasing the risk of atherosclerosis. Over time, the condition can lead to cardiovascular disease and is especially

Researchers are Pioneering Tools for Heart Regeneration

Tue, 08/09/2016 - 9:45am by University of Houston A team of developmental biologists at the University of Houston have uncovered new regulators of heart formation that are easier to deliver into human bodies, and thus have a shorter path to clinical use. Source: Courtesy of Yu Liu Cardiovascular diseases are the leading cause of death in

Genetic error that increases risk of aortic rupture identified

Study sheds light on unexplained enlargement, weakening of aorta By Julia Evangelou Strait July 18, 2016 In young people, aortic aneurysms are most often caused by an inherited condition,such as Marfan syndrome. Standard genetic tests often pinpoint the reason for inheritedaortic disease, but some cases remain medical mysteries. A new study adds lysyl oxidaseto the

Micro heart muscle created from stem cells

Posted: Apr 21, 2016   (Nanowerk News) Scientists at the Gladstone Institutes have invented a new way to create three-dimensional human heart tissue from stem cells ("Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses"). The tissue can be used to model disease and test drugs, and it opens the door for a precision

Stem cell therapy ‘halves number of heart failure deaths’

April 11, 2016 Spectator Health reporter Injecting adult stem cells into the heart could potentially halve the number of deaths from heart failure, a study has suggested. The study, published in the Lancet, found that patients who received the treatment had a 37 per cent lower rate of death and hospitalisation for heart failure-related problems.

Functional Heart Muscle Regenerated in Decellularized Human Hearts

Mon, 03/14/2016 - 12:00pm Massachusetts General Hospital A partially recellularized human whole-heart cardiac scaffold, reseeded with human cardiomyocytes derived from induced pluripotent stem cells, being cultured in a bioreactor that delivers a nutrient solution and replicates some of the environmental conditions around a living heart. (Credit: Bernhard Jank, M.D./Ott Lab/ Center for Regenerative Medicin/, Massachusetts General

‘Broken’ heart breakthrough: researchers reprogram cells to better battle heart failure

UNC School of Medicine scientists overcame a significant barrier to convert scar-making fibroblasts into living, beating cardiomyocytes. Media contact: Mark Derewicz March 3, 2016 CHAPEL HILL, N.C. – Patients with heart failure often have a buildup of scar tissue that leads to a gradual loss of heart function. In a new study published today in the