Parkinson’s Disease

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$3.7 million to help research neurological disorders linked to manganese

Manganese – found in smoke from steel production and coal fires – has been linked to a range of neurological problems often seen with Parkinson’s disease: slowness, stiffness, tremors, anxiety, depression, cognitive changes, and difficulty walking and speaking. Decades ago, federal environmental and public health agencies established manganese-concentration levels of concern for human health, but

Antioxidants Early in Parkinson’s Disease May Halt Degeneration

Northwestern Medicine scientists have identified a toxic cascade that leads to neuronal degeneration in patients with Parkinson's disease (PD) and figured out how to interrupt it, reports a study published September 7 in the journal Science. Intervening with an antioxidant early in the disease process may break the degenerative cycle and improve neuron function in PD,

Medical history can point to earlier Parkinson’s disease diagnosis

Before symptoms become pronounced, there is no reliable way to identify who is on track to develop Parkinson’s disease, a debilitating movement disorder characterized by tremors, slowness of movement, stiffness, and difficulty with balance and coordination. But researchers at Washington University School of Medicine in St. Louis have analyzed Medicare claims data of more than

‘Reprogrammed’ stem cells fight Parkinson’s disease in monkeys

LONDON (Reuters) - Scientists have successfully used “reprogrammed” stem cells to restore functioning brain cells in monkeys, raising hopes the technique could be used in future to help patients with Parkinson’s disease. Since Parkinson’s is caused by a lack of dopamine made by brain cells, researchers have long hoped to use stem cells to restore

Immune system may mount an attack in Parkinson’s disease

A new study suggests that T cells, which help the body’s immune system recognize friend from foe, may play an important role in Parkinson’s disease (PD). The study, published in the journal Nature, was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. “This collaboration between

Waterlogged brain region helps scientists gauge damage caused by Parkinson’s disease

Scientists at the University of Florida have discovered a new method of observing the brain changes caused by Parkinson’s disease, which destroys neurons important for movement. The development suggests that fluid changes in a specific brain area could provide a way to track that damage. The study, published in the journal Brain, was supported by

Immune response linked to Parkinson’s disease

Parkinson’s disease is a degenerative brain disorder that develops when nerve cells in the brain become impaired and eventually die. As these brain cells die, people with Parkinson’s disease may start experiencing involuntary shaking, muscle stiffness, slowed movements, problems with balance, and other symptoms. At first, only a tremor in one hand may be noticeable.

Scientists discover two repurposed drugs that arrest neurodegeneration in mice

University of Cambridge April 20, 2017 A team of scientists who a few years ago identified a major pathway that leads to brain cell death in mice, have now found two drugs that block the pathway and prevent neurodegeneration. The drugs caused minimal side effects in the mice and one is already licensed for use

Your brain cells could be reprogrammed to fight Parkinson’s Disease

IN BRIEF Researchers have reprogrammed existing brain cells in mice into dopamine neurons to reduce their symptoms of Parkinson's disease. This novel approach could be used to treat Parkinson's disease with stem cells which are not transplanted, but induced from patients' own brain cells. SUPPORT CELLS TURNED SUPER CELLS Parkinson’s disease is one of the