Alzheimer’s disease

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Body clock disruptions occur years before memory loss in Alzheimer’s

People with Alzheimer’s disease are known to have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder. Now, new research at Washington University School of Medicine in St. Louis indicates that such circadian rhythm disruptions also occur much earlier in people whose memories are intact

Alzheimer’s gene poses both risk — and benefits

Scientists drilling down to the molecular roots of Alzheimer’s disease have encountered a good news/bad news scenario. A major player is a gene called TREM2, mutations of which can substantially raise a person’s risk of the disease. The bad news is that in the early stages of the disease, high-risk TREM2 variants can hobble the

Novel Protein Signals Rapid Hippocampal Atrophy in AD

The presence of TAR DNA-binding protein 43 (TDP-43) in the hippocampus on postmortem examination is associated with increased rates of hippocampal atrophy in patients with Alzheimer's disease (AD), new research suggests. This association was greatest in individuals who had an intermediate or high likelihood of having AD (ie, neurofibrillary tangle stages B2 and B3), but

$7 million aimed at illuminating the genetics of Alzheimer’s disease

Researchers working to identify genetic factors that raise, lower disease risk by Tamara Bhandari•March 13, 2017 OSCAR HARARI Studies are underway to identify the genetic networks that affect a person's risk of developing Alzheimer's disease. The researchers are aiming to find ways to predict who will develop the neurodegenerative disease, at what age and how

Brain imaging links Alzheimer’s decline to tau protein

Tau is better marker of progression to Alzheimer’s disease than amyloid beta By Julia Evangelou Strait May 11, 2016 Washington University in St. Louis, the SOURCE A study using a new PET imaging agent shows that measures of tau protein in the brain more closely track cognitive decline due to Alzheimer’s disease compared with long-studied

Degenerating Neurons Respond to Gene Therapy Treatment for Alzheimer’s Disease

Postmortem brain studies suggest nerve growth factor safely triggered functional cell growth August 27, 2015 | By Scott LaFee Degenerating neurons in patients with Alzheimer’s disease (AD) measurably responded to an experimental gene therapy in which nerve growth factor (NGF) was injected into their brains, report researchers at University of California, San Diego School of

Saliva seen as possible diagnostic tool for Alzheimer’s disease

By Fredrick Kunkle July 19 Washington Post Your spit might just reveal whether you’re a likely candidate for developing Alzheimer’s disease. That at least is the hope of Canadian researchers whose study suggests that analyzing certain chemical compounds in saliva could provide a cheap, noninvasive way to learn whether the brain has begun to undergo the

Midlife changes in Alzheimer’s biomarkers may predict dementia

July 6, 2015 By Michael C. Purdy MICHAEL C. PURDY Anne Fagan, PhD, professor of neurology (left), and Courtney Sutphen, a graduate student, are lead authors on a study showing that changes in the spinal fluid during middle age may help doctors identify people at risk of developing Alzheimer’s disease later in life. Studying brain scans

Repurposing an “Old” Drug for Alzheimer’s Disease

Posted on April 7, 2015 by Dr. Francis Collins Alzheimer’s disease research is among the many areas of biomedical science that Senator Barbara Mikulski has championed during her nearly 40 years on Capitol Hill. And it’s easy to understand why the Senator is concerned: an estimated 5 million Americans age 65 and older have Alzheimer’s

Repurposed experimental cancer drug restores brain function in mouse models of Alzheimer’s disease

Tuesday, March 31, 2015, 12:00 p.m. NIH-supported research enables clinical trial to explore treatment for most common form of dementia Scientists have found that a compound originally developed as a cancer therapy potentially could be used to treat Alzheimer’s disease. The team demonstrated that the drug, saracatinib, restores memory loss and reverses brain problems in