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SLU Scientist Tackles Debilitating Side Effects of Cancer and Pain Medications

With a pair of RO1 grants from the National Institutes of Health, pain researcher Daniela Salvemini, Ph.D., will embark on two new research projects, studying chemotherapy-induced cognitive impairment, or “chemo brain,” symptoms and unwanted side effects of opioids.  Salvemini, who is professor of pharmacology and physiology at Saint Louis University, has spent her career attempting

In Laboratory, SLU Scientist Turns Off Chemo Pain

In a recent paper published in the journal Pain, Saint Louis University researchers describe their success in an animal model in turning off the excruciating pain that often accompanies a colorectal cancer drug. Daniela Salvemini, Ph.D., professor of pharmacology and physiology at SLU, studies pain pathways, the series of interactions between molecular-level components that lead to

Chemo-loaded nanoparticles target breast cancer that has spread to bone

Breast cancer that spreads often infiltrates bone, causing fractures and intense pain. In such cases, chemotherapy is ineffective because the environment of the bone protects the tumor, even as the drug has toxic side effects elsewhere in the body. Now, scientists at Washington University School of Medicine in St. Louis have developed a nanoparticle that

How to identify drugs that work best for each patient

Implantable device could allow doctors to test cancer drugs in patients before prescribing chemotherapy. Anne Trafton | MIT News Office April 22, 2015 More than 100 drugs have been approved to treat cancer, but predicting which ones will help a particular patient is an inexact science at best. A new device developed at MIT may

SLU Continues Fight to Stop Chemo Pain

December 16, 2013, by Carrie Bebermeyer, St. Louis University staff $1.5 Million from NIH, $600,000 From Leukemia & Lymphoma Society Support Researcher’s Work Daniela Salvemini, Ph.D. is professor of pharmacological and physiological science. With this year’s $600,000 grant from the Leukemia & Lymphoma Society and $1.5 million grant from the NIH, a Saint Louis University investigator is

Newly Discovered Weakness in Cancer Cells Make Them More Susceptible to Chemotherapy, by Staff ~ October 10, 2013 "Our study can contribute to the development of new combined anti-cancer therapies," said Dr. Denis Mottet. "By maintaining a reduced telomere length via HDAC5 inhibition, cancer cells are more sensitive to chemotherapeutic drugs." A new weakness has been discovered in cancer cells that may make them more susceptible

October 10th, 2013|Categories: Cancer, Disease Specific|Tags: , |