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Scientists Discover New Causes of Cellular Decline in Prematurely Aging Kids

In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease. The data points to cellular replication stress and a mistaken innate immune response as culprits, and the team found success in the laboratory in blocking these processes

SLU Researchers Discover BRCA Cancer Cells’ Last Defense

In a new paper published in Nature Communications, a team led by Saint Louis University researcher Alessandro Vindigni, Ph.D. shares new information about how BRCA-deficient cancer cells operate, interact with chemotherapy drugs and what may be their last-ditch effort to survive. Researchers hope their findings may lead to improved chemotherapy drugs and shed light on why

November 29th, 2017|Categories: Around The State, Cancer, Disease Specific|Tags: , , , |

Targeting DNA

Protein-based sensor could detect viral infection or kill cancer cells. Anne Trafton | MIT News Office September 21, 2015 MIT biological engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell and then trigger a specific response, such as cell death. This system can be customized to

September 21st, 2015|Categories: Cancer|Tags: , , , |

New findings shed light on fundamental process of DNA repair

September 8, 2015 Inside the trillions of cells that make up the human body, things are rarely silent. Molecules are constantly being made, moved, and modified — and during these processes, mistakes are sometimes made. Strands of DNA, for instance, can break for any number of reasons, such as exposure to UV radiation, or mechanical

DNA-Guided 3-D Printing of Human Tissue is Unveiled

Technique Produces ‘Organoids’ Useful in Cancer Research, Drug Screening By Nicholas Weiler on August 31, 2015 A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These mini-tissues in a

August 31st, 2015|Categories: Cancer|Tags: , , , |

Reprogramming of DNA observed in human germ cells for first time

Monday, June 8, 2015 - University of Cambridge A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome – the suite of molecules attached to our DNA that switch our genes on and off – is comprehensively erased in early primordial germ cells prior

Stress triggers key molecule to halt transcription of cell’s genetic code

May 27 2015 KANSAS CITY, MO—If DNA is the cookbook of life, then RNA is the scratch paper where the cell writes down its favorite recipes. These recipes could make the pigments of your skin, the vehicles that carry oxygen through your veins, or the signaling molecules that keep cancer in check. Sometimes, when the

Gene-editing technique offers hope for hereditary diseases

Salk scientists use molecular "scissors" to eliminate mitochondrial mutations in eggs and embryos April 23, 2015 LA JOLLA–For thousands of women around the globe carrying a mitochondrial disease, having a healthy child can be a gamble. This set of diseases affect mitochondria, tiny powerhouses that generate energy in the body’s cells and are passed exclusively from

April 23rd, 2015|Categories: General News|Tags: , , , |