Scientists Discover New Causes of Cellular Decline in Prematurely Aging Kids

In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease. The data points to cellular replication stress and a mistaken innate immune response as culprits, and the team found success in the laboratory in blocking these processes

SLU Researchers Discover BRCA Cancer Cells’ Last Defense

In a new paper published in Nature Communications, a team led by Saint Louis University researcher Alessandro Vindigni, Ph.D. shares new information about how BRCA-deficient cancer cells operate, interact with chemotherapy drugs and what may be their last-ditch effort to survive. Researchers hope their findings may lead to improved chemotherapy drugs and shed light on why

Targeting DNA

Protein-based sensor could detect viral infection or kill cancer cells. Anne Trafton | MIT News Office September 21, 2015 MIT biological engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell and then trigger a specific response, such as cell death. This system can be customized to

New findings shed light on fundamental process of DNA repair

September 8, 2015 Inside the trillions of cells that make up the human body, things are rarely silent. Molecules are constantly being made, moved, and modified — and during these processes, mistakes are sometimes made. Strands of DNA, for instance, can break for any number of reasons, such as exposure to UV radiation, or mechanical

3D Printing Cells with DNA Velcro

SEPTEMBER 2, 2015 / TODD DUBNICOFF One of the Holy Grails of stem cell research is growing body parts to replace those damaged by disease or injury. Enormous strides have been made in a key first step: mastering recipes for maturing stem cells into various specialized cell types. But a lawn of, say, liver cells

DNA-Guided 3-D Printing of Human Tissue is Unveiled

Technique Produces ‘Organoids’ Useful in Cancer Research, Drug Screening By Nicholas Weiler on August 31, 2015 A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These mini-tissues in a

Yale team finds why BRCA gene resists cancer treatment

By Bill Hathaway July 2, 2015 Yale University researchers have discovered why a key molecular assistant is crucial to the function of the BRCA2 gene, which in some mutant forms can lead to ovarian and breast cancer in as many as 6 in 10 women. The findings suggest how biochemists might be able to decrease

Reprogramming of DNA observed in human germ cells for first time

Monday, June 8, 2015 - University of Cambridge A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome – the suite of molecules attached to our DNA that switch our genes on and off – is comprehensively erased in early primordial germ cells prior

Gene-editing technique offers hope for hereditary diseases

Salk scientists use molecular "scissors" to eliminate mitochondrial mutations in eggs and embryos April 23, 2015 LA JOLLA–For thousands of women around the globe carrying a mitochondrial disease, having a healthy child can be a gamble. This set of diseases affect mitochondria, tiny powerhouses that generate energy in the body’s cells and are passed exclusively from