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Genome Therapy Could Lead to New Treatment for Life-threatening Blood Disorders

by University of New South Wales   Genome therapy with beneficial natural mutation could lead to new treatment for life-threatening blood disorders By introducing a beneficial natural mutation into blood cells using the gene-editing technique CRISPR, a UNSW Sydney-led team of scientists has been able to switch on production of foetal haemoglobin - an advance

Major breakthrough in the manufacture of red blood cells

Press release issued: 24 March 2017 Researchers have generated the first immortalised cell lines which allow more efficient manufacture of red blood cells. The team, from the University of Bristol and NHS Blood and Transplant, were able to manufacture red blood cells in a more efficient scale than was previously possible. The results, published in

BCL11A-based gene therapy for sickle cell disease passes key preclinical test

September 06, 2016 Decades-old discovery about fetal hemoglobin is on track for clinical trial in the coming year A precision-engineered gene therapy virus, inserted into blood stem cells that are then transplanted, markedly reduced sickle-induced red-cell damage in mice with sickle cell disease, researchers from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center report today in

Calgary doctors develop new stem-cell transplant procedure to cure children with sickle cell anemia

Published on: June 6, 2016 | Last Updated: June 6, 2016 7:23 PM MDT by Alia Dharssi Cardelia Fox, centre, with her sister Tamika Allen and Dr. Greg Guilcher at the Children's Hospital on Monday June 6, 2016. Cardelia suffered from sickle cell anemia and was treated by Dr. Guilcher with stem cells from her

Researcher finds novel way to monitor serious blood disorder using a smart phone

Sept. 22, 2015 Eureka Alert! Gisele Galoustian Florida Atlantic University receives NSF grant A researcher from Florida Atlantic University has come up with a unique way to monitor sickle cell disease -- a serious blood disorder -- using a smart phone. With a $166,935 grant from the National Science Foundation, E. (Sarah) Du, Ph.D., assistant professor

MGH gives grant to low-cost sickle cell diagnostic

Mar 31, 2015 Jessica Bartlett Reporter-Boston Business Journal Massachusetts General Hospital’s Center for Global Health is helping to fund an affordable sickle cell diagnostic, awarding $100,000 to the Whitesides Research Group. Courtesy/Whitesides Research Group A density test can tell whether someone has sickle cell disease. The team, led by Harvard University Chemistry Professor George Whitesides, has been working

SLU Researchers Study Therapy to Relieve Sickle Cell Pain

Newswise, by Staff ~ 1/22/14 Saint Louis University researchers are studying whether ReoPro® (abciximab), a drug currently given to heart patients undergoing angioplasties to open blocked arteries, also could help children and young adults who have severe pain from sickle cell disease. “Sickle cell crises, which are acute episodes that can land patients in the

Chicago Woman Cured of Sickle Cell Disease

Tuesday, June 19, 2012 By: University of Illinois at Chicago ScienceDaily (June 18, 2012) -- Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant. University of Illinois Hospital & Health Sciences System physicians performed the procedure

Correcting Sickle Cell Disease with Stem Cells

Wednesday, September 28, 2011 By: Johns Hopkins Medicine Using a patient's own stem cells, researchers at Johns Hopkins have corrected the genetic alteration that causes sickle cell disease (SCD), a painful, disabling inherited blood disorder that affects mostly African-Americans. The corrected stem cells were coaxed into immature red blood cells in a test tube that

Patient Hopes Experimental Bone Marrow Transplant Will Cure Her of Sickle Cell Disease

Sunday, May 23, 2010 By: Shavonne Potts Salisbury (N.C.) Post More than 80,000 U.S. residents, mainly people of African ancestry, are affected by the inherited blood disorder. Kelly Holloway reaches out for her cat, Jax, a rescued Persian with long cream-colored fur, but she's not quite able to connect with him. It could be the