University of California San Diego School of Medicine

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Novel Imaging Model Helps Reveal New Therapeutic Target for Pancreatic Cancer

Antisense treatment in preclinical models shows effectiveness against deadly tumors June 06, 2016  |  Scott LaFee Pancreatic ductal adenocarcinoma, the most common of pancreatic cancers, is extraordinarily lethal, with a 5-year survival rate of just 6 percent. Chemotherapy treatments are poorly effective, in part due to a high degree of drug-resistance to currently used regimens. In

Stem Cell-derived “Mini-brains” Reveal Potential Drug Treatment for Rare Disorder

September 08, 2015  |  Scott LaFee Using “mini-brains” built with induced pluripotent stem cells derived from patients with a rare, but devastating, neurological disorder, researchers at University of California, San Diego School of Medicine say they have identified a drug candidate that appears to “rescue” dysfunctional cells by suppressing a critical genetic alteration. Their findings are

Degenerating Neurons Respond to Gene Therapy Treatment for Alzheimer’s Disease

Postmortem brain studies suggest nerve growth factor safely triggered functional cell growth August 27, 2015 | By Scott LaFee Degenerating neurons in patients with Alzheimer’s disease (AD) measurably responded to an experimental gene therapy in which nerve growth factor (NGF) was injected into their brains, report researchers at University of California, San Diego School of

Newly Discovered Cells Regenerate Liver Tissue Without Forming Tumors

Hybrid hepatocytes proliferate and replenish liver mass after chronic liver injuries in mice August 13, 2015  |  Heather Buschman, PhD The mechanisms that allow the liver to repair and regenerate itself have long been a matter of debate. Now researchers at University of California, San Diego School of Medicine have discovered a population of liver cells

Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support

July 23, 2015  |  Bonnie Ward A new study by researchers at University of California, San Diego School of Medicine reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer. The finding offers a novel target for better treating

Enzyme’s Role in Human Health, Disease, Discovered

Fri, 06/19/2015 - 9:05am Seth Augenstein, Digital Reporter A process called phosphorylation is the human body’s method of tagging proteins, and sending them to do the work of biology. Scientists have identified how most of this is done inside cells – but what happens outside cells – which includes processes causing wounds to heal, bones

Spinal cord axon injury location determines neuron’s regenerative fate

Injury to a spinal cord axon after a major branch point. Researchers at University of California, San Diego School of Medicine report a previously unappreciated phenomenon in which the location of injury to a neuron’s communication wire in the spinal cord — the axon — determines whether the neuron simply stabilizes or attempts to regenerate.