Antisense treatment in preclinical models shows effectiveness against deadly tumors June 06, 2016 | Scott LaFee Pancreatic ductal adenocarcinoma, the most common of pancreatic cancers, is extraordinarily lethal, with a 5-year survival rate of just 6 percent. Chemotherapy treatments are poorly effective, in part due to a high degree of drug-resistance to currently used regimens. In
September 08, 2015 | Scott LaFee Using “mini-brains” built with induced pluripotent stem cells derived from patients with a rare, but devastating, neurological disorder, researchers at University of California, San Diego School of Medicine say they have identified a drug candidate that appears to “rescue” dysfunctional cells by suppressing a critical genetic alteration. Their findings are
Postmortem brain studies suggest nerve growth factor safely triggered functional cell growth August 27, 2015 | By Scott LaFee Degenerating neurons in patients with Alzheimer’s disease (AD) measurably responded to an experimental gene therapy in which nerve growth factor (NGF) was injected into their brains, report researchers at University of California, San Diego School of
Hybrid hepatocytes proliferate and replenish liver mass after chronic liver injuries in mice August 13, 2015 | Heather Buschman, PhD The mechanisms that allow the liver to repair and regenerate itself have long been a matter of debate. Now researchers at University of California, San Diego School of Medicine have discovered a population of liver cells
July 23, 2015 | Bonnie Ward A new study by researchers at University of California, San Diego School of Medicine reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer. The finding offers a novel target for better treating
Fri, 06/19/2015 - 9:05am Seth Augenstein, Digital Reporter A process called phosphorylation is the human body’s method of tagging proteins, and sending them to do the work of biology. Scientists have identified how most of this is done inside cells – but what happens outside cells – which includes processes causing wounds to heal, bones
Injury to a spinal cord axon after a major branch point. Researchers at University of California, San Diego School of Medicine report a previously unappreciated phenomenon in which the location of injury to a neuron’s communication wire in the spinal cord — the axon — determines whether the neuron simply stabilizes or attempts to regenerate.