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Macular degeneration linked to aging immune cells

As people age, their immune systems age, too. And new research at Washington University School of Medicine in St. Louis suggests that aging immune cells increase the risk for age-related macular degeneration, a major cause of blindness in the United States. Studying mice and cells from patients, the researchers found that as immune cells called

New gene-editing technology partially restores vision in blind animals

November 16, 2016Salk researchers have discovered, for the first time, how to place DNA in specific locations in non-dividing cells LA JOLLA—Salk Institute researchers have discovered a holy grail of gene editing—the ability to, for the first time, insert DNA at a target location into the non-dividing cells that make up the majority of adult

November 16th, 2016|Categories: Blindness|Tags: , , , , |

CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells

A potential precision medicine approach for treating vision loss January 27, 2016 Columbia University Medical Center (CUMC) and University of Iowa scientists have used a new gene-editing technology called CRISPR to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at

NIH-funded study points way forward for retinal disease gene therapy

Monday, May 4, 2015 Benefits for Leber congenital amaurosis peak after one to three years, then diminish Gene therapy for Leber congenital amaurosis (LCA), an inherited disorder that causes vision loss starting in childhood, improved patients’ eyesight and the sensitivity of the retina within weeks of treatment. Both of these benefits, however, peaked one to

Same musicians: brand new tune

May 14 2013 Stowers investigators discover how an unusual interplay of signaling pathways shapes a critical eye structure KANSAS CITY, MO—A small ensemble of musicians can produce an infinite number of melodies, harmonies and rhythms. So too, do a handful of workhorse signaling pathways that interact to construct multiple structures that comprise the vertebrate body.