Washington University in St. Louis

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Missouri Researchers Join Hunt For One Of Medicine’s Elusive Quarries: Artificial Blood

By ALEX SMITH • APR 5, 2017 Former railroad worker Johnnie Matz has been donating blood, platelets and plasma at the Community Blood Center in Kansas City for 45 years. ALEX SMITH / KCUR 89.3 Medical researchers have made a lot of progress developing artificial versions of organs like the heart, lungs and kidneys, but

$3.6 million to fund personalized 3-D brain maps to guide neurosurgeries

Academic-industry partnership aims to improve brain surgery By Tamara Bhandari April 5, 2017 Neurosurgeons must avoid cutting into parts of the brain responsible for key functions such as language (orange) and vision (green), but individuals vary in where such functions are located (each of the top images compared with the bottom images above). Researchers are creating

Surprising culprit in nerve cell damage identified

Findings suggest ways to block nerve cell damage in neurodegenerative diseases By Julia Evangelou Strait March 22, 2017 Nerve axons (left) serve as the electrical wiring of the nervous system. Scientists have implicated a specific molecule in triggering a self-destruct program in axons that leads to their degeneration (right). Since axonal degeneration is a common thread

$7 million aimed at illuminating the genetics of Alzheimer’s disease

Researchers working to identify genetic factors that raise, lower disease risk by Tamara Bhandari•March 13, 2017 OSCAR HARARI Studies are underway to identify the genetic networks that affect a person's risk of developing Alzheimer's disease. The researchers are aiming to find ways to predict who will develop the neurodegenerative disease, at what age and how

Unraveling autism

A multifaceted approach aims to detect, treat and even reverse the disorder. BY REBECCA BOYLE, January 3, 2017 Washington University in St. Louis - Like many patients visiting a doctor’s office, Kim Sebenoler started out her appointment by heading to the nearest restroom to give a urine sample. But her visit to the lab of

New topical immunotherapy effective against early skin cancer

Combination of two drugs reduces precancerous skin lesions By Julia Evangelou Strait November 21, 2016 Washington University dermatologist Lynn Cornelius, MD, (left) conducts a skin exam with patient Robert Manchester. Manchester is a participant in a clinical trial testing the effectiveness of a new topical immunotherapy against precancerous skin lesions called actinic keratosis, often found

Researchers launch first clinical trial for Wolfram syndrome

Many people with rare genetic disease die prematurely by Jim Dryden•November 10, 2016 The drug dantrolene is a muscle relaxant approved to treat patients with cerebral palsy, multiple sclerosis and muscle spasticity. Recent research also suggests it can prevent the destruction of insulin-secreting beta cells in animal models of Wolfram syndrome. Researchers at Washington University

Measuring damage to brain networks may aid stroke treatment, predict recovery

Functional MRI scans provide crucial data for stroke patients by Tamara Bhandari •July 11, 2016 JOSHUA SIEGEL Understanding the network of connections between brain regions — as depicted above — and how they are changed by a stroke, is crucial to understanding how stroke patients heal, according to new research from Washington University School of Medicine

Gut microbes’ metabolite dampens proliferation of intestinal stem cells

Finding may provide clues to limitations of potential IBD treatment By  Tamara Bhandari June 2, 2016 Intestinal stem cells are sequestered in pockets in the lining of the intestine to avoid contact with a metabolite produced by beneficial microbes in the gut. That metabolite — butyrate — restricts the proliferation of stem cells, shown here in