Wolfram Syndrome

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Researchers launch first clinical trial for Wolfram syndrome

Many people with rare genetic disease die prematurely by Jim Dryden•November 10, 2016 The drug dantrolene is a muscle relaxant approved to treat patients with cerebral palsy, multiple sclerosis and muscle spasticity. Recent research also suggests it can prevent the destruction of insulin-secreting beta cells in animal models of Wolfram syndrome. Researchers at Washington University

Potential treatment target identified for rare form of diabetes

June 23, 2015 By Jim Dryden URANO LABORATORY-WASHINGTON UNIVERSITY This microscopic image shows dying insulin-secreting cells (red) from a diabetic mouse pancreas. A cell-death cascade was set off by a process that occurs when harmful molecules spill from one part of the cell into other areas where they don’t belong. Cell death can trigger numerous