Turning CAR-T Tech Against Solid Tumors by Targeting Protein Fragments in Cancer Cells

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CAR-T therapies, which arm a patient’s own immune cells with cancer-fighting proteins, are currently used to treat some patients with blood cancers. But the technology has been hard to apply to other cancers, partly because of a lack of tumor-specific antigens for the T cells to target. Now, a research team at the University of Pennsylvania’s Children’s Hospital of Philadelphia (CHOP) has developed a new type of CAR-T cell designed to fight solid tumors by targeting proteins inside cancer cells. Read more…