Study reveals obesity-related trigger that can lead to diabetes

Researchers at Washington University School of Medicine in St. Louis have found that a defect in an enzyme called APT1 interferes with the ability to secrete insulin, contributing to the development of Type 2 diabetes in people who are overweight or obese. In this microscopic image of the surface of an insulin-secreting beta cell from a mouse with diabetes, granules containing insulin are green; granules containing a protein affected by APT1 are red; and the yellow granules are those that release excess insulin due to a defect in APT1. Read more…